We carried out a
research to investigate the
potential risk of exposure to petroleum fumes among automobile mechanics in
Lagos, Nigeria. Structured questionnaire was administered to elicit information
on their exposure to petroleum products.
Automobile mechanics in their line of occupation are constantly exposed
to petroleum products. These products contain toxic compounds such as Benzene,
Toluene, Ethyl benzene and Xylene, (BTEX). Venous blood was taken from exposed
subjects for Methaemoglobin (MetHb), Packed Cell Volume (PCV), haemoglobin and
BTEX.
One of the effects of benzene in the body is the production of methaemoglobin
(MetHb) which differs
from haemoglobin. Haemoglobin accepts and transports oxygen only when the iron
atom is in its ferrous form. When haemoglobin becomes oxidized, iron is
converted to the ferric state (Fe3+) or MetHb. Methemoglobin cannot bind oxygen, MetHb lacks the electron that is needed to form a bond with oxygen
and, thus, is incapable of oxygen transport.
Our results reveal that the mean methaemoglobin value in the
blood of the automobile mechanics (3.68%-7.33%) were significantly higher
(p<0.05) than the control subjects (0.83%). MetHb level was directly
proportional to the duration of exposure
with 0-5 years exposure having (0.4%) and 21-30 years of exposure having (13%).
We discovered that mechanics with many
years of exposure has high MetHB in their blood. Since red blood cells are
continuously exposed to various oxidant stresses, blood normally contains MetHb
levels of between 1and 3% . Considering that MetHb has little affinity for oxygen, transport of the later to
cells is hindered resulting in functional anaemia . As the level of MetHb
increases, symptoms like shortness of breath, palpitation, anxiety and confusion
occur . Humans are commonly exposed to benzene and other VOCs through the
pulmonary and dermal pathways.
Methemoglobin saturation is expressed as the percentage of
hemoglobin in the methemoglobin state; That is MetHb as a proportion of Hb.
·
1-2%
Normal
·
Less
than 10% metHb - No symptoms
·
10-20%
metHb - Skin discoloration only (most notably on mucous membranes)
·
30-50%
metHb - Fatigue, confusion, dizziness, tachypnea, palpitations
·
50-70%
metHb - Coma, seizures, arrhythmias, acidosis
·
Greater
than 70% metHb - Death
Our study has established a strong evidence between increased exposure to petrol fumes among automobile mechanics and level of MetHb. The awareness of effects of exposure to petroleum fumes and use of personal protective equipment by automobile mechanics to reduce exposure to petroleum products in their workshops is highly recommended.